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KMID : 0812020060120010063
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Korean Journal of Neurogastroenterology and Motility
2006 Volume.12 No. 1 p.63 ~ p.68
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β-Adrenergic Receptor Sensitivity, Mood State and Colonic Sensation in Patients with Irritable Bowel Syndrome
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Yu Bum-Hee
Kang Eun-Ho
Kim Hyun-Seo
Rhee Poong-Lyul
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Abstract
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Background/Aims: Autonomic abnormalities and mood state have been frequently reported in patients with irritable bowel syndrome (IBS). This study was designed to assess β-adrenergic receptor sensitivity and mood in IBS patients without depressive or anxiety disorders, and to examine the relationship among β-adrenergic receptor sensitivity, mood and colonic sensation in IBS patients.
Methods: Eighteen IBS patients were compared with the same number of age- and sex- matched normal control subjects. To assess β-adrenergic receptor sensitivity, we measured the chronotropic 25 dose (CD25). The balloon distension test was performed to measure colonic sensation in the IBS patients. The Hamilton Rating Scale for Depression (HAM-D) and the Hamilton Rating Scale for Anxiety (HAM-A) were also used.
Results: The β-adrenergic receptor sensitivity was significantly higher in the patient group than in the control group, and the IBS patients showed higher scores on the HAM-D and HAM-A. The β-adrenergic receptor sensitivity was positively correlated with HAM-A scores in all IBS patients and the perception of discomfort in the constipation-predominant IBS patients.
Conclusions: These results suggest that β-adrenergic receptor sensitivity is increased in IBS patients who do not have depressive or anxiety disorders. Anxiety and altered β-adrenergic receptor sensitivity may be related to colonic sensation in some IBS patients. (Kor J Neurogastroenterol Motil 2006;12:63-68)
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KEYWORD
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Irritable bowel syndrome:β-Adrenergic receptor:Anxiety:Colonic perception
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